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User manual for HPA axes research Glycocorticoid endocrine disrupters are dynamic regulators of all physiologic system of mammals. It is important to understand the effect of glucocorticoids in biological and medical research. HPA-axes control circular and stress-related glycocorticoid secretions. It examines strategy and best practice for the investigation of HPA axial physiology. a.

.. Glocorticoidhormone ( "Cortisol" and "Corticosterone" - CORT) are the effectors of the hypothalamic-pituitary-adrenal (HPA) neuendocrine system.

The CORT is a systematic intracellular signalling whose levels vary in a predictable manner with the daytime and increase dramatically with environment-related and psychic stress factors. It is used by practically every single cellular and physiologic system in the human organism to optimise performances according to circular, ecological and physiologic requirements. Dysfunctions in the standard HPA axial profile are associated with a multitude of physiologic and psychic problems.

In spite of a number of trials that have so far diagnosed the effects of glucocorticoids on molecules, cells and the system, new effects of glucocorticoids and associated statuses are still being rapidly demonstrated in the academic world. The purpose of this user manual is to give a basic survey of the conceptional, technological and functional know-how to help people involved in and evaluating HPA axes research.

The first step is to investigate the anatomic and hormone component of the HPA axes and their field of action. Subsequently, we investigate strategy and best practice for systematically manipulating and accurately measuring HPA axial activities. Experimentally, we use techniques that allow a better comprehension of the physiologic action of CORT, especially as these action affect the following cerebral work.

The research is crucial in identifying the mechanism by which changes in HPA axial functions can help in pathophysiological processes.

User manual for HPA axes research. - pubMed

Glocorticoidhormone ( "Cortisol" and "Corticosterone" - CORT) are the effectors of the hypothalamic-pituitary-adrenal (HPA) neuendocrine system. The CORT is a systematic intracellular signalling whose levels vary in a predictable manner with the daytime and increase dramatically with environment-related and psychic stress factors. It is used by practically every single cellular and physiologic system in the human organism to optimise performances according to circular, ecological and physiologic requirements.

Dysfunctions in the standard HPA axial profile are associated with a multitude of physiologic and psychological problems. In spite of a number of trials that have so far diagnosed the effects of glucocorticoids on molecules, cells and the system, new effects of glucocorticoids and associated statuses are still being rapidly demonstrated in the academic world.

The purpose of this user manual is to give a basic survey of the conceptional, technological and functional know-how to help people involved in and evaluating HPA axes research. The first step is to investigate the anatomic and hormone component of the HPA axes and their field of action. Subsequently, we investigate strategy and best practice for systematically manipulating and accurately measuring HPA axial activities.

Experimentally, we use techniques that allow a better comprehension of the physiologic action of CORT, especially as these action affect the following cerebral work. The research is crucial in identifying the mechanism by which changes in HPA axial functions can help in pathophysiological processes.

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