Khin mon

Chin mon

Mr. Khin Khine Zar Mon from the University of California, Davis, California UCD with expertise in genetics, immunology, microbiology. The Khin Mon - Khin's Stored Places. Address Khin Mon, phone number, send e-mail, public records & background search.

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Map and model the effects of the administration of bulk drugs on Myanmar's widespread prevalence of filariasis

If not otherwise indicated, the information provided in this section shall apply. In order to emphasize the advances of the National Program for the Elimination of Lymphatic Filariasis (NPELF) between 2000 and 2014, this document discusses the geographic spread of the LF, the magnitude and effects of the implementations of the Mass drug administration (MDA) and the first signs of the decrease in transfer in five districts.

LF distributions were defined by depicting historic and basic population prevalence figures obtained by the NPELF. Summary information on MDA deployment, reporting rate of cover, and monitoring ofentinel sites has been aggregated. From the available population prevalence information, a statistic framework was designed to forecast community levels by year of use. Transmittance Assessment Survey techniques (TAS), which measure the incidence of childhood antigenaemia ( "Ag"), were used to establish whether the incidence was below a threshold at which recurrence was unlikely.

NF's highest base line incidence was found in the Central Valley area. Work on MDA implementations covered 45 boroughs, which represent the vast majority indigenous people, with a total of 60 drugs in use. Issues related to drugs supplies and community conflicts have been highlighted and MDA has been disrupted in someistricts.

Overall, significant decreases in NF prevalence were observed, especially after the first 2 to 3 laps of the MDA, which were assisted by the corresponding models. Southeast Asia has the highest incidence of diseases in the world[5-7], and many nations have adopted the Global Program to Eliminate Lymphatic Filariasis (GPELF) policy, which includes the key objectives of i) disrupting TB through at least five annually sessions of the MDA covering 65% of the entire community, and ii) preventing the condition through MDA and MMDP by providing a treatment plan for lymphoedema and hydrocolic edema in basic healthcare.

Myanmar, formerly known as Burma, is one of the most endemic Southeast Asian nations with a high NF incidence, where the illness is due to the Wuchereria bancrofti virus and is spread by the Culex quarquefasciatus mosquito[9, 10]. Myanmar, like many other regional states, has a long tradition of filiary epidemicity, with a high incidence of infections in several areas[7, 9, 10].

Myanmar NPELF relied on historic proof, domestic dates, and cartographic surveys carried out in the late 90s to delineate the country's indigenous areas[11]. Peninsula and the main hinterland proved to be the most endemic, with an estimate of 41 million inhabitants (~ ?% of the entire population) in 45 provinces.

Myanmar NPELF's main early priority was to disrupt transfer by decreasing survival through MDA using two anti-filar agents, dietylcarbamazine (DEC) and Albendazole. In the last 15 years, the NPELF has carried out programme activity in the field of upscaling and downscaling, among them the development of a national LF removal scheme for the WHO in 2000, the launch of the MDA in 2001 and the achievement of 43 district targets in 2013, the conduct of an on-going monitoring of guard sites since 2000 and the conduct of the first epidemiological studies to demonstrate effects and reduce prevalence in 2008 and 2014, using World Health Organization (WHO) guidelines[12-14].

In order to emphasize the programme activity in Myanmar, this document discusses and mappings the geographic spread of NF, sketches the progression and impacts of programme activity, modells the decrease in the prevalence, and emphasizes the first signs that the decrease in Prevalence is so low that the transfer in five distributions is likely to be unsustainable.

The 15 administration areas are further subdivided into counties, municipalities, cites, municipalities, stations, streets (groups of neighbouring villages) and hamlets. Recent 2014 figures show that Myanmar has 51.5 million inhabitants, a demographic coverage of 75 per sq km, and more than a third of the country's inhabitants live in metropolitan areas[15].

NPELF is part of the Ministry of Health and Sport (MoHS) and is in charge of implementing the MDA and MMDP activity across the country[16]. Myanmar had a population of 65 in 2000, which the NPELF still uses for programme planning despite the recent changes in administration borders, which formed 74 in 2014.

Every suburban healthcare center offers healthcare provision to a group of five to ten communities who have voluntary staff and who also help with the LF's MDA activity as communal drugs dispensers. In 2000, the end-emicity state of each of the 65 Myanmar boroughs was determined on the basis of collected historic information, domestic reporting, and fast response maps in 19 boroughs as part of a WHO multi-country study[11].

On this basis, 45 of the 65 counties were considered end-emic. WHO's largest map study covered a population of 70 cities at random in the 19 counties. Antigenemia ( "Ag") incidence was measured using the immunochromatographic test map (BinaxNOW Filariasis, Alere Inc., Scarborough, ME) of 100 volunteers from select stations and homes, all in each home except the critically ill and those who were not present at the point of interview.

In order to emphasize the end-emic spread across the entire nation prior to the scale-up of MDA-related activity, WHO Predictor Point datasets in the 45 end-emic regions were re-mapped by reimporting the initial chart and digitalizing the points with a default point function utility in the Geographic Information System ArcGIS 10 of ESRI, Redlands, CA.

In order to describe the progression and effects of the reduction in transmission-related activity, summary information on the transposition of the MDA, reporting cover and monitoring of sending inel locations (including random sample locations) was provided. Work on MDA deployment has been carried out in accordance with the GPELF policy, which requires each of the districts, also known as the IU, to complete at least five round MDAs, covering the whole of >?%[13].

Key pre-MDA mobilisation measures in the municipalities include television coverage, broadcast, community medical consultations by program and primary medical personnel (i.e. healthcare workers, birth attendants, skilled nurses) and the dissemination of brochures with the support of civic organisations and regional agencies. Supervision and assessment of the scheme was carried out through periodic supervision of the sending agencies and sampling points at municipal as well as municipal levels.

Those fields were analyzed to evaluate the impacts before and after the introduction of the MDA. It was then sent to the main site where all information was kept in registries and analyzed at the community site as well. The basic observational base of the guard site incidence was charted using ArcGIS 10 of ESRI, Redland and CA according to the geographic boundaries of the municipality.

In order to better elucidate the decline in incidence associated with the MDA, a statistic framework was designed to forecast the variation in Mf incidence in a municipality since the last evaluation, which varies by location. Figures have been screened to cover only agglomerations for which both a base Mf value (i.e. one measure before one MDA) and at least one later sendinel and/or sample Mf value were available.

For several Mf readings taken in the same municipality in the same year, an average was calculated and used. Among the variable types examined for the models were the basic Mf value, the most recent Mf value (this may have been either a basic Mf value or the results of a follow-up survey), the number of MDA laps since the start of the MDA program and the number of MDA laps and years since the last Mf value was surveyed.

First all Mf coefficients were converted with log10 (x + ), because an asymmetry was found in the qq diagram when modeling non-modified datasets. Then a generalized linear model (GLM, feature "glm") in the statistic setting of R2 (R Development Core Team, 2012) was used to forecast the mean Mf value for each municipality in one year.

Transmittance Assessments Surveys (TAS) are a standardized decision-making tool[13] designed and endorsed by the WHO and used to measure the 2014 decrease in transmittance in five areas from three different areas, among them the Magway District (Minbu District), Sagaing District (Kathur, Kalay, Tamu Districts) and Mandalay District (Pyin Oolwin District).

Before the MDA was discontinued, each of the districts had at least five actual MDA sessions, showed proof of > ? coverage and showed a significant decrease in Ag (< %) and Mf (< %) prevalence levels at all locations. Kathur, Kalay and Tamu districts discontinued the MDA at the end of 2007 and were investigated in 2008 in clusters according to the WHO standards at that point in history for the decrease in the number of transmissions.

Therefore, the TAS polls carried out in 2014 were regarded as the second TAS or "TAS 2" for these three wards. For these three counties, the results of the first clusters or " TAS 1 " from the 2008 polls and the results of TAS 2 in 2014 were presented. WHO's NF Pred ivalence Questionnaire found a Filaria disease virus in the range of 0% to >COPY11%.

Spatial ly these observations were analyzed to obtain an estimate of the filtric virus incidence in each borough, highlighting the main filtrative focal point in the key area of the state. On the basis of these domestic and historic records, the NPELF identified the 45 indigenous communities of the IU ( "Districts") that needed an MDA, most of which were located in the lowlands of the Cental Valley area ( Figs. 1b and c).

For each IU, the predominance of the Mf Sendinel site was assessed before the MDA was implemented. Sendinel Sentinels have been implemented gradually over a 13 year span between 2001 and 2013. The MDA and Mf-Sentinel location information for end-emic ILUs in each area is summarized in Figure 1. Geographic boundaries of the municipality were used to map all guard location prevalence information, indicating similar pattern of end-emicity in the Central Valley area ( Figure 1d).

Mf base mean averages were highest in Sagaing (7.9%), Mandalay (5.2%) and Magway (3.6%), with the highest in Shwe Bo (15.1%), Kyauk Se (14.7%) and Pakokku (9.1%) in 2002, 2003 and 2002 respectively. All in all, the basic Mf base mean ratios were lower in the Ayeyawaddy (0.5%), Kayin (0.002%) and Tanintharyi (0.5%) counties, with the highest Mf ratios measured in Pathein (2.4%), Myawaddy (0.1%) and Dawei (1.8%) in 2004, 2012 and 2008.

Refer to Supplementary Table 2 for basic information on the prevalence of theentinel site. In 2001, the first MDA was introduced in two ITUs, namely Magway and Theyet Districts in the Magway region (Fig. 2). These are the only available side effects information and it is recognised that the system of reports needs to be reinforced.

Not until 2013 did MDA activity expand: education of primary medical personnel, lobbying materials), ongoing difficulties in obtaining sufficient DEC, and security-related questions in the two indigenous Kachinistricts. As a result of this scale of MDA, a further 21 MDAs were dealt with in 2013, coinciding with the reduction of MDA in 2 Minbu and Pyin Oo Lwin districts (IUs) when they met the TAS requirement and a further 4 Rakhine state interim suspensions due to safety related questions.

Extra Attachment 3 summarizes the scale-up and scale-down of MDA-related activity between 2001 and 2014. Initial collection results were significantly different between 15. Chart 3a shows trend prevalences based on the number of MDAs. With the exception of two municipalities, all showed a significant decrease in the prevalence in the 13 years for which available figures were available, especially after two to three MDA laps in which the rate was between 0 and 8.8%.

Amapura and Pakokku cities, which recorded an increase in sampling population ( "outliers"), were eliminated to better investigate general trend. As a result, 138 single Mf site scores were obtained and incorporated into the further study, showing that after two to three MDA sessions the incidence was significantly lower and was between 0 and 5.9%.

Municipalities for which sendinel location and sample data were available were sampled between 0 and 12 laps of MDA. Based on the most recent evaluation of the Mf population in the same municipality, a prediction of the Mf population in a municipality in one year was made. Its most significant factor was an interactive term that consisted of two predictors (the last Mf population ( login + ) and the number of managed MDASs ( login + ).

Second highest factor was base line incidence (log +?). Taken together, this shows that although the number of MDA laps is the most important determinant, the framework reflecting the base number also influences the results, i.e. two MDA laps in a high base area will not decrease the incidence as much as two MDA laps in a low base area, even if the most recent Mf value is the same in both areas.

It may be due to the low number of available datapoints. However, the prediction was that the incidence of MDA would rise if there were more laps between MDAs. This seems, however, to be an artefact of MDA management; previous experience was usually gathered after two MDA sessions, but after three MDA sessions in Mandalay.

It shows that three Mandalay round meetings of MDA had less impact on Prevalence than two Mandalay round meetings elsewhere, indicating that Mandalay round meetings of MDA were specifically less efficient. Modeled datas are shown in Fig. 3b clearly mirrors the same trends in the prevalence of the local population.

First two MDA laps led to a significant decrease in Prevalence, followed by a much smaller decrease in following MDA laps while maintaining previous Revalence. A similar tendency is indicated by the model, e.g. an area with 30% basic prevalence that falls to 6.5% after the first two MDAs, suggesting a 78% decrease.

Next two MDA laps continue to fall, but less drastically, to 3.5%, and two more MDA laps lower the incidence to 2.8%. The effect of the first two MDA laps is a 73% decrease to 3.9% for locations with a base line of 15% (the next two MDA laps decrease the decrease to 2.3%, with little further effect after four MDA laps).

In areas with a base line of 7%, the effect of the first two laps of MDA is a 69% decrease to a 2.2% decrease in prevalence (the next two MDA laps decrease to 1.4% decrease, with little effect after four MDA laps). During 2008, the first clusters or " TAS 1 " for the districts of Kalay, Kathar and Tamu did not find ICT-positive kids among the 2269, 3003 and 3085 among the 16, 31 and 25 school districts respectively that had been screened.

By 2014, the pre-TAS evaluations showed that all five ILUs had a satisfactory number of MDA sessions and a high reporting rate of therapy cover of >COPY11%. There were 5 to 7 crews, each with three people: supervisors, collectors and technicians. Township Medical Officer was in charge of information and coordination of activity with the Township Education Department and the principals of the chosen schools prior to the poll.

Name, gender, ages and grades were captured for each chosen infant and 100 votes were taken at 100 www.ikt. Blut für die IKT. Treatment was given to the two positively offspring and the parent and township medical officer visited for further supervision if necessary. All in all, Myanmar NPELF has made good programme headway with the success of MDA expansion, the significant reduction in the prevalence of MDA and the introduction of post-MDA vigilance in five areas.

Previous advances can be traced back to several elements that have been singled out as determining elements for the NF programme's effectiveness, as found in other countries[18, 19], among which: i) generally low transfer intensities, initially found at the major ity of Mf intensities

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